The burden of heart failure (HF) continues to rise and besides its significant mortality risk, the medical costs spent on HF hospitalizations are expected to increase from $21 billion in 2012 to $53 billion in 2030.

Código de aprobación: GKB-NON-2024-00711

Evidence suggests that risks for orthostatic hypotension and falls are elevated immediately after initia- tion of antihypertensive medication.

Código de aprobación: GKB-NON-2024-00448

Pulmonary Arterial Hypertension (PAH) is a serious pulmonary vascular disease characterized by elevated resting mean pulmonary arterial pressure (mPAP).

Código de aprobación: GKB-NON-2024-00243

Emergency Departments (ED) constitute one of the cornerstones of virtually any healthcare system when it comes to managing a high volume of patients and are also the source of most hospitalized patients

Código de aprobación: GKB-NON-2024-00273

It is essential to find reliable biomarkers for early diagnosis and prognosis of acute heart failure (AHF) for its mitigation.

This study examines the potential long-term joint association between smoking and diet quality as modifiable risk factors concerning cardiovascular diseases (CVDs) incidence and all-cause mortality among current and former smokers.

Código de aprobación: GKB-NON-2024-00200

According to updated Lake-Louise Criteria, impaired regional myocardial function serves as a supportive criterion in diagnosing myocarditis.

Código de aprobación: GKB-NON-2024-00192

Generalist clinicians often are asked to formally assess patients’ cardiac risk prior to surgery.

Código de aprobación: NON-2024-1498

The first WHO Global report on hypertension has been released. The background of this report is emerging hypertension burden in globe, attributing in cardiovascular disease and all cause mortality.

Atrial fibrillation (AF) is the most common sustained arrhythmia and it is a major public health problem worldwide associated with substantial morbidity and mortality.

Código de aprobación: NON-2024-2034

Occult atrial fibrillation (AF) is a common cause of cryptogenic stroke.

Código de aprobación: NON-2024-2025

The popularity of e-cigarettes has risen dramatically over the last few years, particularly among the younger population.

Código de aprobación: NON-2024-1489

We aimed to explore the prevalence of atherosclerosis by using multi-view ultrasound examination of the carotid arteries and its association with clinical risk factors in a middle-aged population at low to intermediate risk of cardiovascular disease (CVD).

Código de aprobación: NON-2024-1473

Obstructive sleep apnea (OSA) is a common disorder and males are known to be more susceptible it; its estimated prevalence is approximately 22% in men and 17% in women.

Código de aprobación: NON-2024-0664

High blood pressure is the leading cause of death and disability globally and an important treatable risk factor for cardiovascular, cerebrovascular and chronic kidney diseases.

Various predictive models have been developed for predicting the incidence of coronary heart disease (CHD), but none of them has had optimal predictive value.

Código de aprobación: NON-2023-11714

Measurement of the left ventricular outflow tract diameter (LVOTd) in echocardiography is a common source of error when used to calculate the stroke volume.

Código de aprobación: NON-2023-11725

Outcomes are poor, even in women with ejection fraction recovery.

Código de aprobación: NON-2023-7569

Tachycardia–bradycardia syndrome (TBS) occasionally coexists with paroxysmal atrial fibrillation (AF) and is an indication for pacemaker implantation (PMI) if it is symp- tomatic.

Código de aprobación: NON-2023-8556

Findings are consistent with current guidelines prioritizing the coronary artery calcium score over the polygenic risk score in predicting patient risk.

Patients with other cardiovascular risk factors face added risk after high-dose radiation.

Código de aprobación: NON-2023-5546

In an important new study in 2022, researchers compared computed tomography angiography (CTA) with invasive coronary angiography as a first step in defining coronary anatomy in patients with stable chest pain and suspected coronary artery disease (CAD).

Código de aprobación: NON-2023-2100

Cardiac CT appears promising as a tool to detect an embolic source in ischemic stroke.Although transthoracic echocardiography (TTE) is commonly performed for evaluation of potential cardioembolic sources in patients with ischemic stroke.

Código de aprobación: NON-2023-0483

Patients who develop postoperative atrial fibrillation (AF) after noncardiac surgery have higher risk for stroke and death than do patients who do not develop postop AF.

Código de aprobación: NON-2023-0354

A large population-based study from the UK documented elevated CVD risk in people with a broad range of autoimmune diseases.

Substantial evidence, mostly observational, has established that a Mediterranean diet (i.e., emphasizing fruits, vegetables, legumes, cereals, white meat, fish, and olive oil) is optimal for primary prevention of cardiovascular (CV) disease.

Vasovagal syncope is extremely common and lacks effective therapies. Early reports of ablation of the ganglionated plexus in the atrium appeared to show benefit but were from observational studies. Now, researchers report findings of a small, randomized trial of cardioneuroablation for reducing syncope recurrence.

Código de aprobación: NON-2023-0488

Troponin levels have become the gold standard for the diagnosis of myocardial infarction (MI) because of their sensitivity and spec-ificity. More recently, high-sensitivity cardiac troponin (hs-cTn) levels have largely replaced prior troponin measurements. Sensitivity should be increased with these newer hs-cTn levels, but there is concern that specificity may suffer.

Código de aprobación: NON-2022-7135

Life’s Essential 8^™ adds healthy sleep and a 100-point scale for measuring and tracking optimal cardiovascular health.

Código de aprobación: NON-2022-12188

In DECAAF II, fibrosis-guided ablation for persistent AF failed to improve outcomes compared with standard pulmonary vein isolation.

Código de aprobación: NON-2022-12193

A meta-analysis suggests improvement in discrimination is modest.

Código de aprobación: NON-2022-12192

Hypertensive disorders of pregnancy and low birth weight carry the greatest risk.

Investigators have previously found an association between adverse pregnancy outcomes and future cardiovascular risk. To confirm an association between atherosclerotic cardiovascular disease (ASCVD) in postmenopausal women and a history of adverse pregnancy outcomes, the authors performed the current study.

Código de aprobación: PP-CVP-GLB-0351

Predicting Cardiovascular Risks in a Contemporary Population 

The widely accepted pooled cohort equations overestimate 5-year risk in a cohort of Veterans Affairs patients, with implications for statin eligibility.The pooled cohort equations (PCE) were developed to estimate the risk for an initial atherosclerotic cardiovascular disease (ASCVD) event. However, these equations were derived from data in longitudinal studies before widespread use of statin therapy.

Código de aprobación: PP-CVP-GLB-0307

Implantable Cardiac Devices: Accessibility, Variability and Complications

Access to medical care varies tremendously around the globe. It is especially in advanced technology that this variability exists, and particularly between underdeveloped and developed countries. Pacemakers and defibrillators are advanced technologies that are less available to patients in underdeveloped areas. In developed countries, devices are often removed and discarded while extended battery life still remains.

Código de aprobación: PP-CVP-GLB-0292

How Common Is ACS After Transcatheter Aortic-Valve Replacement?

Acute coronary syndrome is infrequent, presents most often as non-STEMI, but is associated with high early mortality.

Although as many as 50% of patients who undergo transcatheter aortic-valve replacement (TAVR) have known coronary artery disease, the incidence of acute coronary syndrome (ACS) after TAVR is unknown.

Código de aprobación: PP-CVP-GLB-0283

Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome

Prescription of supplemental oxygen to critically ill adults in an intensive care unit (ICU) is a ubiquitous intervention practiced for decades. Surprisingly, research on the correct supplemental oxygen dose for critically ill patients has only been available within the last decade.

Código de aprobación: PP-IMU-GLB-0001

Long-Term Blood Pressure Variability Is Associated with Structural and Functional Changes to the Heart

Greater BP variability in early adulthood correlated with worse echocardiographic features at middle age.

Visit-to-visit blood pressure variability (BPV) has been associated with adverse cardiovascular outcomes, independent of BP level. To understand if BPV in early adulthood is associated with later subclinical alterations in cardiac structure and function, researchers used data from a U.S.-based community cohort study (CARDIA) in which participants aged 18 to 30 at enrollment underwent eight BP evaluations over 25 years of follow-up and an echocardiogram at year 25.

Código de aprobación: PP-CVP-GLB-0284

Aortic Stenosis and Dyslipidemia

A study using a Mendelian randomization design finds causal associations between elevated total cholesterol and LDL levels and AS.

To date, aortic stenosis (AS) has no recommended prevention strategies, and statins have failed to slow disease progression in randomized trials. However, questions remain about whether dyslipidemia is associated with the condition.

Código de aprobación: PP-CVP-GLB-0281

Transcatheter or surgical Aortic valve replacement

Acute coronary syndrome is infrequent, presents most often as non-STEMI, but is associated with high early mortality.

Although as many as 50% of patients who undergo transcatheter aortic-valve replacement (TAVR) have known coronary artery disease, the incidence of acute coronary syndrome (ACS) after TAVR is unknown.

Código de aprobación: PP-CVP-GLB-0273

Even in patients whose CAC=0, smoking, diabetes, and hypertension are risk factors for ASCVD events and should trigger consideration of preventive therapies.

Código de aprobación: NON-2022-3969

Titers against T. cruzi can serve as quantitative markers of Chagas disease activity, progression to cardiomyopathy, and consideration for antitrypanosomal therapy.

Código de aprobación: PP-CVP-GLB-0577

More than half of small AAAs showed slow growth that might allow for less-frequent monitoring. In older patients with small abdominal aortic aneurysms (AAAs), the best follow-up interval is unclear, but most patients receive annual assessment of maximum transverse diameter (MTD).

Código de aprobación: PP-CVP-GLB-0578

Carbohydrate-containing foods and beverages have variable effects on health. So-called “poor-carbohydrate foods” have low amounts of fiber, more refined grains than whole grains, and a high glycemic index (a measure of how much 50 gm of carbohydrate raises the blood glucose level).

Código de aprobación: PP-CVP-GLB-0587

Although unhealthy lifestyles apparently mediate only a small proportion of socioeconomic inequity in health, a healthy lifestyle remains the foundation of CVD prevention. Lower socioeconomic status (SES) is associated with higher total mortality, cardiovascular disease (CVD) mortality, and CVD events.

Código de aprobación: PP-CVP-GLB-0489

The questions of whom to treat for hypertension and how aggressively to treat have received con- siderable recent attention, with at least some partial answers.

Código de aprobación: PP-CVP-GLB-0491

Almost 75% of patients in a meta-analysis sustained silent brain infarcts after the procedure.Transcatheter aortic-valve implantation (TAVI) is one of the great recent advances in cardiovascular medicine.

Código de aprobación: PP-CVP-GLB-0446

Reducing sympathetic nerve activity causes disintegration of nerve fibers in arterial walls and reduces atheroma size.

During the past 30 years, the interacting roles of lipid metabolism and the immune system (inf lam-mation) in the pathogenesis of atherosclerosis have become clear.

NON-2022-9881

A study suggests that heavy calcification is associated with slower expansion of the aneurysm.

NON-2022-10964