Your Patient Doesn't Need a Broad-Spectrum Antibiotic

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Your Patient Doesn't Need a Broad-Spectrum Antibiotic

Almost half of patients who are hospitalized for pneumonia or urinary tract infections (UTIs) receive unnecessary extended-spectrum antibiotics.

Código de aprobación: GKB-NON-2024-00451

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Natural History of Autoimmune Gastritis

Two types of gastric atrophy with inflammation (atrophic gastritis) are chronic infection with Helicobacter pylori and autoimmune gastritis (AIG).

Código de aprobación: GKB-NON-2024-00600

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Asthma Can Be Exacerbated by Household Cleaning Products

Among 37,000 people in a web-based cohort, ≈1700 reported having controlled asthma, and ≈500 reported having uncontrolled asthma.

Código de aprobación: GKB-NON-2024-00450

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Reduced protein levels in latex gloves may play an alternative approach to lowering latex sensitization risks among health workers; a cross-sectional analytical study

Latex gloves are widely used as personal protective equipment in healthcare settings due to their favorable properties, including protection against biological hazards, elasticity, and dexterity

Código de aprobación: GKB-NON-2024-00709

Spontaneous Normalization of Subclinical Hypothyroidism

Subclinical hypothyroidism — above-normal level of thyroid-stimulating hormone (TSH) but normal free thyroxine (T4) — becomes more common with age.

Código de aprobación: GKB-NON-2024-00114

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What Is the Incidence of Statin-Induced Diabetes?

Statins are known to raise risk for diabetes modestly. In this meta-analysis of individual participant data from 23 randomized statin trials, researchers estimated the incidence of this adverse effect.

Código de aprobación: GKB-NON-2024-00449

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Covert or Minimal Hepatic Encephalopathy Is a Common Complication of Cirrhosis

Covert or minimal hepatic encephalopathy (C/MHE) has been associated with falls, motor vehicle accidents, and worsened liver-related outcomes from cirrhosis, but diagnosis requires specialized testing and frequently is missed.

Código de aprobación: GKB-NON-2024-00446

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Serum eosinophil-derived neurotoxin: a new promising biomarker for cow’s milk allergy diagnosis

Influenza Vaccination of Pregnant Mothers Protects Their Infants

Cow’s milk allergy (CMA) is the most prevalent cause of food allergy (FA) in infants and children younger than 3 years.

Código de aprobación: GKB-NON-2024-00561

Nonpharmacologic Approaches to Improving or Preserving Cognitive Function

Influenza Vaccination of Pregnant Mothers Protects Their Infants

Maternal vaccination protects infants from diseases such as pertussis and COVID19 during the first few months of life.

Código de aprobación: NON-2024-2057

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Artificial Intelligence Accurately Identified Tumor Origin in Cancer of Initially Unknown Primary Site

Influenza Vaccination of Pregnant Mothers Protects Their Infants

Cancer of unknown primary site often causes pleural and peritoneal effusions, and cytological analysis by pathologists using traditional methods can be inaccurate.

Código de aprobación: GKB-NON-2024-00447

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Association between the triglyceride glucose index and obstructive sleep apnea and its symptoms: results from the NHANES

Influenza Vaccination of Pregnant Mothers Protects Their Infants

Sleep-related disorders have a substantial impact on an individual’s daily activities and overall quality of life. Nevertheless, among American adults aged 20–79 years, 16.3% reported of experiencing sleep problems.

Código de aprobación: GKB-NON-2024-00549

Influenza Vaccination of Pregnant Mothers Protects Their Infants

Influenza Vaccination of Pregnant Mothers Protects Their Infants

Maternal vaccination protects infants from diseases such as pertussis and COVID19 during the first few months of life.

Código de aprobación: NON-2024-2057

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The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study

The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study

Intrahepatic cholestasis during pregnancy (ICP) is a common complication of pregnancy, characterized by elevated bile acid levels, skin pruritus, and elevated transaminase levels in the second half of pregnancy.

Código de aprobación: GKB-NON-2024-00441

Anaphylaxis: first clinical presentation, subsequent referral practise, and suspected elicitor—an observational study

Anaphylaxis: first clinical presentation, subsequent referral practise, and suspected elicitor—an observational study

Anaphylaxis is the most severe form of allergy and fast diagnosis and treatment is therefore crucial. The diagnosis is challenging if the patient has an atypical presentation of symptoms and, in particular, if the patient has no previous history of anaphylaxis.

Código de aprobación: GKB-NON-2024-00438

Predictive nomograms based on gammaglutamyl transpeptidase to prealbumin ratio for prognosis of hepatocellular carcinoma patients without microvascular invasion

Predictive nomograms based on gammaglutamyl transpeptidase to prealbumin ratio for prognosis of hepatocellular carcinoma patients without microvascular invasion

Hepatocellular carcinoma (HCC) presents a significant threat to individuals and healthcare systems due to its high recurrence rate.

Código de aprobación: GKB-NON-2024-00432

Effect of photobiomodulation therapy on headache, and fatigue in patients with chronic rhinosinusitis: a randomized controlled study

Effect of photobiomodulation therapy on headache, and fatigue in patients with chronic rhinosinusitis: a randomized controlled study

Chronic rhinosinusitis (CRS) is a debilitating disease that resists medical treatment.

Código de aprobación: GKB-NON-2024-00429

The effects of Mediterranean diet on cardiovascular risk factors, glycemic control and weight loss in patients with type 2 diabetes: a meta-analysis

The effects of Mediterranean diet on cardiovascular risk factors, glycemic control and weight loss in patients with type 2 diabetes: a meta-analysis

To explore the impact of the Mediterranean diet on cardiovascular risk factors, glycemic control and weight loss in patients with type 2 diabetes (T2D) by a meta-analysis of randomized controlled trials (RCTs).

Código de aprobación: GKB-NON-2024-00426

Weight Loss and Subsequent Diagnosis of Cancer

Weight Loss and Subsequent Diagnosis of Cancer

Weight loss is often a presenting manifestation of cancer; this association was explored in more detail with this prospective cohort study involving female nurses and male health professionals.

Código de aprobación: NON-2024-2058

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DGPRI, a new liver fibrosis assessment index, predicts recurrence of AFP‑negative hepatocellular carcinoma after hepatic resection: a single‑center retrospective study

DGPRI, a new liver fibrosis assessment index, predicts recurrence of AFP‑negative hepatocellular carcinoma after hepatic resection: a single‑center retrospective study

Abdominal ultrasonography and alpha-fetoprotein measurement are the standard methods for diagnosing and monitoring HCC.

Código de aprobación: GKB-NON-2024-00275

Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta‑analysis

Allergic diseases constitute a significant global public health concern for children in the twenty-first century.

Código de aprobación: GKB-NON-2024-00272

The effect of periodic resistance training on obese patients with type 2 diabetic nephropathy

Resistance training is an exercise against resistance designed to train the endurance and strength of muscle.

Código de aprobación: GKB-NON-2024-00269

Association of TGF-β1 Polymorphism and TGF-β1 Levels With Chronic Hepatitis C and Cirrhosis: A Systematic Review and Meta-Analysis

Despite the extensive research conducted on the relationship between transforming growth factor-beta 1 (TGF-β1) polymorphisms and levels and the onset and development of liver disease, there are still certain gaps that need to be addressed.

Código de aprobación: GKB-NON-2024-00265

Longitudinal BMI change and outcomes in Chronic Obstructive Pulmonary Disease: a nationwide population-based cohort study

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The association between longitudinal body mass index (BMI) change and clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) has not fully investigated.

Código de aprobación: GKB-NON-2024-00262

The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults

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This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context of evolving knowledge over the last few decades.

Código de aprobación: GKB-NON-2024-00190

Can Personalized Risk-Reduction Strategies Improve Cognition in Older Adults?

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Evidence is mixed on whether multidomain interventions — simultaneously targeting lifestyle, behavioral, and medical risk factors — can improve cognition or delay cognitive decline.

Código de aprobación: NON-2024-1500

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Dietary calcium is inversely associated with hepatitis B virus infection: an analysis of US National Health and Nutrition and Examination Survey (NHANES) 2007-2020

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There have been studies on the relationship between hepatitis B virus (HBV) infection and diet. We hypothesized HBV infection is related to dietary calcium intake, but the evidence is limited.

Código de aprobación: GKB-NON-2024-00202

Hepatic arterial hemodynamics and model for end-stage liver disease (MELD) scores in chronic liver disease: insights from Doppler ultrasonography

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Doppler ultrasonography is essential to provide insights into hemodynamic alterations and liver function changes in pre-cirrhotic and cirrhotic patients.

Código de aprobación: GKB-NON-2024-00194

Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK

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As mounting evidence suggests a higher incidence of adverse consequences, such as disruption of the immune system, among patients with a history of COVID-19, we aimed to investigate post-COVID-19 conditions on a comprehensive set of allergic diseases including asthma, allergic rhinitis, atopic dermatitis, and food allergy.

Código de aprobación: GKB-NON-2024-00199

Transfusion Strategy for Hospitalized Patients with Anemia

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A restrictive transfusion strategy (hemoglobin [Hb] cutoff, <7 g/dL) is accepted widely as the standard of care for most hospitalized patients with anemia, but controversy remains for some subgroups (NEJM JW Gen Med May 1 2021 and JAMA 2021; 325:552).

Código de aprobación: NON-2024-2048

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Pheochromocytoma: A Contemporary Case Series

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In recent years, pheochromocytomas are detected increasingly in patients with incidentally dis covered adrenal masses, rather than in patients with classic adrenergic symptoms.

Código de aprobación: NON-2024-2054

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Elucidating Community-Acquired Pneumonia in Immunocompromised Individuals

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While immunocompromised hosts (ICH) clearly have elevated risk for pneumonia, data are scant regarding epidemiology and outcomes associated with community acquired pneumonia (CAP) in this population.

Código de aprobación: NON-2024-1504

Obesity Is Associated with Altered Rectal Sensitivity in Chronic Constipation

Defecation dysfunction may contribute to chronic constipation (CC), but the impact of obesity on anorectal physiology in CC remains unclear.

Código de aprobación: GKB-NON-2024-00095

Meta‑analysis of the Relationship Between Neutrophil to Lymphocyte Ratio and Nasal Polyps

Nasal polyps are benign, multifactorial mucosal protrusions that form in the nasal cavity.

Código de aprobación: GKB-NON-2024-00094

Thyrotoxicosis and Risk for Cognitive Disorders in Older Adults

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Thyrotoxicosis, defined as a low level of serum thyroid-stimulating hormone (TSH), can result from either a primary thyroid disorder (endogenous) or overtreatment of hypothyroidism (exogenous).

Código de aprobación: NON-2024-1494

Incidence and clinical impact of bile ducts changes after multibipolar radiofrequency ablation for hepatocellular carcinoma

Image-guided percutaneous ablation techniques represent a significant advancement in the treatment of liver malignancies.

Código de aprobación: NON-2024-2035

High-Dose Flu Vaccine Lowers Severity in Breakthrough Cases

High-dose influenza vaccine is recommended for adults older than 65; it contains four times more antigen than standard-dose vaccines, elicits higher antibody responses, and is thought to confer better protection.

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Código de aprobación: NON-2023-11734

How Does Septoplasty Compare with Medical Management for Nasal Obstruction?

Septoplasty is a common surgery for nasal obstruction, but we don’t have controlled trials to compare it with medical management.

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Código de aprobación: NON-2023-11736

Should Patients with Persistent Dyspnea After Pulmonary Embolism Be Referred for Exercise Therapy?

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Cardiopulmonary rehabilitation programs are a cornerstone of managing chronic obstructive pulmonary disease and cardiovascular disorders and improve patients’ symptoms, exercise capacity, and quality of life (QoL).

Código de aprobación: NON-2023-11735

Psychological Factors in Patients with Refractory Heartburn and Reflux

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Psychological factors are thought to be associated with symptoms attributed to gastroesophageal reflux disease (GERD).

Código de aprobación: NON-2023-11732

Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study

Clinical Improvement in Leg Cellulitis Is Slow

Eczema is a group of conditions which cause inflamed and irritated skin, and atopic dermatitis (AD) is the most common form of eczema in childhood.

Código de aprobación: NON-2024-2032

Clinical Improvement in Leg Cellulitis Is Slow

Clinical Improvement in Leg Cellulitis Is Slow

Cellulitis is both very common and very commonly misdiagnosed: Recent studies have shown that 30% to 60% of patients with presumed cellulitis actually have something else

Código de aprobación: NON-2023-11733

Circulating Advanced Oxidation Protein Products (AOPPs) increases the risk of metabolic syndrome among adults: A systematic review and meta‑analysis

Circulating Advanced Oxidation Protein Products (AOPPs) increases the risk of metabolic syndrome among adults: A systematic review and meta‑analysis

Several studies have highlighted the possible role of advanced oxidation protein products (AOPPs) in promotion of metabolic syndrome (MetS).

Código de aprobación: NON-2024-1482

Mendelian randomization analysis to analyze the genetic causality between different levels of obesity and different allergic diseases

Mendelian randomization analysis to analyze the genetic causality between different levels of obesity and different allergic diseases

The causal relationship between obesity and different allergic diseases remains controversial.

Código de aprobación: NON-2024-1487

Prediction of outcomes in patients with metabolic dysfunction‑associated steatotic liver disease based on initial measurements and subsequent changes in magnetic resonance elastography

Prediction of outcomes in patients with metabolic dysfunction‑associated steatotic liver disease based on initial measurements and subsequent changes in magnetic resonance elastography

The prognosis of metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with liver fibrosis.

Código de aprobación: NON-2024-1491

Do Muscle-Strengthening Activities Enhance the Mortality Benefit of Aerobic Exercise?

Do Muscle-Strengthening Activities Enhance the Mortality Benefit of Aerobic Exercise?

Evidence suggests that regular moderate-to-vigorous aerobic physical activity lowers risk for premature death and that this risk can be lowered further by adding muscle-strengthening activity, such as lifting weights and doing calisthenics.

Código de aprobación: NON-2023-11019

Frailty is related to serum inflammageing markers: results from the VITAL study

Frailty is related to serum inflammageing markers: results from the VITAL study

Frailty describes an age‑associated state in individuals with an increased vulnerability and less resilience against adverse outcomes.

Código de aprobación: NON-2024-1446

High‑frequency audiometry in the diagnosis of tinnitus

High‑frequency audiometry in the diagnosis of tinnitus

Subjective tinnitus is an unpleasant perception of sound without any external acoustic stimulus.

Código de aprobación: NON-2024-1449

Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis

Interleukin (IL)-36 family cytokines have received increasing attention, especially in the fields of inflammation and immunity research.

Código de aprobación: NON-2024-0662

Types of Inheritance and Genes Associated with Familial Meniere Disease

Meniere disease (MD) is a rare disorder of the inner ear defined by sensorineural hearing loss (SNHL) associated with episodes of vertigo and tinnitus.

Código de aprobación: NON-2024-0471

Association between continuous glucose monitoring‑derived glycemic control indices and urinary biomarkers of diabetic kidney disease: Hyogo Diabetes Hypoglycemia Cognition Complications study

Glomerular damage and proximal tubular damage play an important role in the pathogenesis of diabetic kidney disease.

Código de aprobación: NON-2024-0467

Interstitial Lung Abnormalities as Incidental Findings on Lung CT

The term “interstitial lung abnormalities” (ILAs) is used increasingly to describe certain incidental findings on lung computed tomography (CT).

Código de aprobación: NON-2023-11020

Exercise Works to Lower Blood Pressure

Hypertension continues to be a leading risk factor for cardiovascular disease and stroke.

Código de aprobación: NON-2023-9732

Is Gastroparesis Misdiagnosed Often?

Gastroparesis and functional dyspepsia are sensorimotor disorders with similar symptoms.

Código de aprobación: NON-2023-11018

Intestinal Barrier and Gut Microbiota in Patients with Overlapping Irritable Bowel Syndrome and Functional Dyspepsia

Disturbances in the intestinal barrier and gut dysbiosis have been observed in patients with functional bowel diseases.

Código de aprobación: NON-2024-0666

Does AKI Beget Worsening CKD?

Does AKI Beget Worsening CKD?

Whether episodes of acute kidney injury (AKI) lead to worsening chronic kidney disease (CKD) still is under debate, and some countries now incentivize stricter renal monitoring of patients following hospitalizations for AKI.

Código de aprobación: NON-2023-8603

Blood eosinophil related to maternal allergic rhinitis is associated with the incidence of allergic rhinitis in offspring: COCOA study

Blood eosinophil related to maternal allergic rhinitis is associated with the incidence of allergic rhinitis in offspring: COCOA study

The identification of allergic rhinitis (AR) in early life is important for the target of intervention.

Código de aprobación: NON-2023-11700

New Guidelines for Pulmonary Rehabilitation for Patients with Chronic Respiratory Diseases

New Guidelines for Pulmonary Rehabilitation for Patients  with Chronic Respiratory Diseases

Chronic respiratory diseases, particularly chronic obstructive pulmonary disease (COPD), contribute to quality-of-life declines, anxiety, and depression for many patients.

Código de aprobación: NON-2023-9736

Using the canadian egg ladder in children with food protein-induced enterocolitis syndrome: a case series

Using the canadian egg ladder in children with food protein-induced enterocolitis syndrome: a case series

Current management of food protein-induced enterocolitis syndrome (FPIES) involves strict avoidance of the offending food for 12–18 months, followed by oral food challenge (OFC) under physician supervision.

Código de aprobación: NON-2023-11723

Dietary approaches to stop hypertension (DASH) diet improves hepatic fibrosis, steatosis and liver enzymes in patients with non‑alcoholic fatty liver disease: a randomized controlled trial

Dietary approaches to stop hypertension (DASH) diet improves hepatic fibrosis, steatosis and liver enzymes in patients with non‑alcoholic fatty liver disease: a randomized controlled trial

Recent evidence suggests that adherence to dietary approaches to stop hypertension (DASH) diet can be effective in managing non-alcoholic fatty liver disease (NAFLD).

Código de aprobación: NON-2023-11727

The Post-COVID Clinical Landscape 2 Years Out

The Post-COVID Clinical Landscape 2 Years Out

At 1 year after acute COVID-19, survivors still had excess risk for persisting symptoms and development of new diseases.

Código de aprobación: NON-2023-9737

Lifestyle practices that reduce seasonal PM2.5 exposure and their impact on COPD

Lifestyle practices that reduce seasonal PM2.5 exposure and their impact on COPD

Particulate matter (PM) is a major air pollutant that has led to global health concerns and can cause and exacerbate chronic obstructive pulmonary disease (COPD).

Código de aprobación: NON-2023-9724

The role of the atopy patch test in the diagnostic work‑up of non‑IgE gastrointestinal food allergy in children: a systematic review

The role of the atopy patch test in the diagnostic work‑up of non‑IgE gastrointestinal food allergy in children: a systematic review

Non–IgE mediated gastrointestinal (non-IgE-GI) food-induced allergic disorders encompass numerous and different clinical pictures. Some of these are well-characterized, such as Food Protein-Induced Allergic Proctocolitis (FPIAP), Food ProteinInduced Enterocolitis Syndrome (FPIES), Food Protein-Induced Enteropathy Syndrome (FPE), and Eosinophilic Gastrointestinal Disorders (EGIDs) (including Eosinophilic Esophagitis (EoE), Allergic Eosinophilic Gastroenteritis (AEG), and Eosinophilic Colitis (EC)).

Código de aprobación: NON-2023-9725

Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment

Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment

The implications of disaccharidase deficiency as it pertains to neurogastroenterology and motility disorders has been a mystery for the past several decades.

Código de aprobación: NON-2023-9727

Antibiotic stewardship in the ICU: time to shift into overdrive

Antibiotic stewardship in the ICU: time to shift into overdrive

Over the past decade, antibiotics have been prescribed in a large and steady way around the world. Their use carries a double risk; an individual risk of adverse events, as well as a collective risk of antibiotic resistance .

Código de aprobación: NON-2023-9728

Fecal microbiota transplant delivered via invasive routes in irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Fecal microbiota transplant delivered via invasive routes in irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Irritable bowel syndrome (IBS) is a frequently encountered disorder in gastroenterology clinics, defined by periodic chronic abdomen pain and altered bowel habits.

Código de aprobación: NON-2023-8558

Bariatric Surgery Is Superior to Medical Management for Long-Term Diabetes Control

Bariatric Surgery Is Superior to Medical Management for Long-Term Diabetes Control

Investigators previously reported pooled 3-year outcomes of four randomized, single-center trials of bariatric surgery or medical management for patients with type 2 diabetes.

Código de aprobación: GKB-NON-2024-00113

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Ultrasound for Detecting Hepatic Steatosis

Ultrasound for Detecting Hepatic Steatosis

In a large retrospective study, ultrasound’s sensitivity was 89% and specificity was 81%.

Código de aprobación: NON-2023-7528

Nighttime Blood Pressure Predicts 10-Year Mortality

Nighttime Blood Pressure Predicts 10-Year Mortality

Daytime or clinic BP readings were not as good, and white-coat hypertension did not confer excess risk.

Código de aprobación: NON-2023-7527

Contrast‐induced anaphylaxis: does it occur in the medical environment and is it being responded to appropriately?

Nighttime Blood Pressure Predicts 10-Year Mortality

Recent reports have estimated the incidence of severe adverse reactions with non-ionic iodinated contrast media (ICM) to be 0.01%, but these rare reactions may be fatal.

Código de aprobación: NON-2023-8565

Peripheral blood eosinophilia in adult asthmatic patients and its association with the severity of asthma

Telerehabilitation and Unsupervised Treadmill Training Both Are Better Than Nothing for COPD Rehab

Asthma is a diverse disease characterized by chronic air- way inflammation. It is defined by a history of respi- ratory symptoms such as wheezing, chest tightness, shortness of breath, and cough that can fluctuate over time and in intensity along with variable expiratory air- flow limitation.

Código de aprobación: NON-2023-8555

Low Serum Creatinine: Marker for Adverse Perioperative Outcomes?

Low Serum Creatinine: Marker for Adverse Perioperative Outcomes?

Preoperative serum creatinine levels lower than 0.65 — and especially lower than 0.45 mg/dL — were associated with excess postoperative complications and death.

Código de aprobación: NON-2023-4423

Telerehabilitation and Unsupervised Treadmill Training Both Are Better Than Nothing for COPD Rehab

Telerehabilitation and Unsupervised Treadmill Training Both Are Better Than Nothing for COPD Rehab

These findings support a role for telehealth to boost access to pulmonary rehabilitation after chronic obstructive pulmonary disease exacerbations.

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Código de aprobación: NON-2023-6627

Autoimmunity and Long COVID: Are They Linked?

Autoimmunity and Long COVID: Are They Linked?

Circulating antinuclear autoantibodies were detectable up to 12 months after recovery and were associated with cytokine levels, inflammation markers, and persistent symptoms.

Código de aprobación: NON-2023-4424

How Common Is Osmotic Demyelination Syndrome When Correcting Hyponatremia?

When Correcting Hyponatremia?

A multicenter study showed that rapid overcorrection was common but osmotic demyelination was rare.

Código de aprobación: NON-2023-5549

Colorectal Neoplasia Prevalence at ≥10-Year Follow-Up Screening Colonoscopy

Colorectal Neoplasia Prevalence at ≥10-Year Follow-Up Screening Colonoscopy

Prevalence of advanced neoplasm was much lower at repeat screening colonoscopies than at all screening colonoscopies.

Código de aprobación: NON-2023-3763

Primary Hyperparathyroidism with “Normal” Parathyroid Hormone Levels

Primary Hyperparathyroidism with “Normal” Parathyroid Hormone Levels

In a large cohort study, 6% of patients with primary hyperparathyroidism had PTH levels ≤50 pg/mL.

Código de aprobación: NON-2023-3765

No Clear Benefit for Home Oxygen in COPD with Moderate Hypoxemia

No Clear Benefit for Home Oxygen in COPD with Moderate Hypoxemia

Long-term oxygen therapy lowers short-term mortality in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia, but benefits for those with moderate hypoxemia are less clear.

Código de aprobación: NON-2023-2096

FODMAP-Lowering Diet for Patients with Irritable Bowel Syndrome

In a primary care–based trial, the diet was moderately more effective than antispasmodic medication.

Código de aprobación: NON-2023-1445

Does Subclinical Hyperthyroidism Predispose People to Fractures?

In patients with subclinical hyperthyroidism, 27 excess fractures occurred per 10,000 person-years. Overt hyperthyroidism confers risk for fractures due to uncompensated bone resorption.

Código de aprobación: NON-2023-1448

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Trends in Imaging for Suspected Urinary Stones in the Emergency Department

Trends in Imaging for Suspected Urinary Stones in the Emergency Department  

Ultrasound appears to be underused, and CT overused, for patients presenting acutely with suspected nephrolithiasis.

Código de aprobación: NON-2023-1447

Misinformation of COVID‑19 vaccines and vaccine hesitancy

Health misinformation can kill people, both directly and indirectly. During a public health crisis such as the COVID-19 pandemic, exposure to misinformation about the virus’ spread, symptoms of infection, testing opportunities, and prevention methods can lead to erroneous appraisals of the threat, maladaptive coping behaviors, and a range of fatal consequences.

Código de aprobación: NON-2023-2633

The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID‑19

The World Health Organization (WHO) announced the pandemic of coronavirus disease 2019 (COVID-19) in March 20201. COVID-19 is a respiratory syndrome with a wide range of severity that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Código de aprobación: NON-2023-2632

Maternal Intake of Ultraprocessed Foods Is Associated  with Excess Risk for Pediatric Obesity

Healthful maternal diets during pregnancy and child rearing have been associated with lower risk for childhood obesity. Might maternal intake of ultraprocessed foods specifically influence risk for pediatric obesity?

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Código de aprobación: NON-2023-1172

Is Muscle Strengthening Associated with Lower Mortality in Older Adults?

In this study, researchers used a U.S. national health interview database to explore survival benefits of muscle strengthening activities in 115,000 community-dwelling older adults. Muscle-strengthening activity was categorized into one of four levels (from 0 to 28 sessions weekly), as was moderate-to-vigorous aerobic physical activity (from <10 to >300 minutes weekly).

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Código de aprobación: NON-2023-1170

Is Thunderstorm Asthma a Real Thing?

“Thunderstorm asthma” is thought to be triggered by the combination of wind, humidity, and lightning, which ruptures grass pollen and mold spores and breaks them into aerosolized particles. Such particles could cause asthma symptoms and exacerbations.

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Código de aprobación: NON-2022-9882

How Long Does COVID-19 Associated Smell and Taste Dysfunction Last?

Two and a half years into the pandemic, a clearer understanding of the natural history of COVID-19associated smell and taste dysfunction finally is emerging. Three groups have evaluated the timeline of such dysfunction.

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Código de aprobación: NON-2023-0479

Balancing Access and Supervision in a Walking Program for Patients with Peripheral Vascular Disease

A home-based, behavior-change program improved 6-minute walking distance by about 25 m over usual care.

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Código de aprobación: NON-2022-8878

Diagnostic effect of artificial intelligence solution for referable thoracic abnormalities on chest radiography: a multicenter respiratory outpatient diagnostic cohort study

Chest radiography is the most commonly used radiologic examination to screen chest diseases and monitor patients with thoracic abnormalities, including lung cancer and pneumonia. However, interpreting chest radiographs is challenging and prone to misreading.

Código de aprobación: NON-2022-14805

Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero

The World Health Organization (WHO) recommends exclusive breastfeeding for the first 6 months of life. Breastfeeding has been shown to protect against infections and improve child cognition.

Código de aprobación: NON-2023-0356

Chronic Kidney Disease Classification Predicts Short‑Term Outcomes of Patients Undergoing Pancreaticoduodenectomy

The incidence of pancreatic tumors has increased over the last several decades.With advances in surgical techniques and perioperative management, the indications for pancreatic surgery have broadened to include older patients with comorbidities.

Código de aprobación: NON-2023-0355

Fatal anaphylaxis: Epidemiology and risk factors.

Patients with food, medication, and venom allergy live with the knowledge that they are at risk to experience anaphylaxis if they encounter their trigger at any time. This can negatively impact quality of life and impact their decision making.

Código de aprobación: NON-2022-7133

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Respiratory-related death in individuals with incident asthma and COPD: a competing risk analysist

Hundreds of millions of people worldwide are diagnosed with chronic respiratory diseases, and approximately four million premature deaths are attributed to these conditions each year. Asthma and chronic obstructive pulmonary disease (COPD) are the most prevalent chronic respiratory diseases, affecting 358 and 174 million people respectively.

Código de aprobación: NON-2022-0146

 

Cancer and Autoimmune Diseases Are Underrecognized Manifestations of Primary Immunodeficiency

More than 40% of deaths among immunodeficient patients are due to noninfectious causes.

More than 400 identified genetic defects cause primary immunodeficiency (PID), with a prevalence of roughly 1 in 1000 people. Although we think of infections as being the major cause of morbidity and death in such patients, underappreciated manifestations include allergy, autoimmunity and inflammation, lymphoproliferation, and malignancy.

Código de aprobación: NON-2022-15495

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Abdominal Obesity Is Associated with Early All-Cause Mortality

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Abdominal Obesity Is Associated with Early All-Cause Mortality

Mortality risk increased nearly linearly in men and women with waist circumferences greater than 90 cm and 80 cm, respectively.

Higher body-mass index (BMI) is associated with earlier all-cause mortality, but BMI fails to distinguish between muscle mass and fat mass or between deleterious visceral and abdominal fat and protective gluteal and thigh fat.

Código de aprobación: PP-IMU-GLB-0068

Normocalcemic Primary Hyperparathyroidism: A Cross-Sectional Study

Normocalcemic primary hyperparathyroidism-IM: A Cross-Sectional Study

Bone findings with this condition were more favorable than those of its hypercalcemic counterpart.

Patients with primary hyperparathyroidism (PHPT) occasionally present with consistently normal serum calcium even after correction for serum albumin — a variant known as normocalcemic PHPT.

Código de aprobación: PP-IMU-GLB-0019

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Treating Obesity and Other Conditions in Undeserved Patients

Systemic Racism, Healthcare Disparities, and the Social Determinants of Health

The national conversation about systemic racism on a broad societal level has direct corollaries in healthcare. The coronavirus pandemic has exacerbated what were known to be large disparities across society in health and healthcare.

Código de aprobación: PP-IMU-GLB-0040

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Whole-Grain Foods and Postprandial Glycemia

In patients with type 2 diabetes, less-processed whole-grain products are associated with lower postprandial glucose levels.

Dietary recommendations for patients with diabetes include consumption of whole-grain foods. However, whole-grain foods differ in the extent to which they are processed: For example, wheat, brown rice, and oats can be finely milled or less processed.

Código de aprobación: PP-IMU-GLB-0122

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Iron deficiency after weight loss surgery

Iron deficiency is a common, delayed consequence of malabsorptive weight-loss surgery, especially in younger women.

Bariatric surgery can reduce the impact of obesity-associated comorbidities, but it increases the risk for iron deficiency (ID) and iron deficiency anemia (IDA).

Código de aprobación: PP-IMU-GLB-0039

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Worldwide Trends in Cholesterol Levels

Almost 40 years of international data show that the highest mean non-HDL cholesterol levels shifted to East and Southeast Asia from high-income Western regions. With the epidemiological transition (the movement toward noncommunicable disease with economic development), cardiovascular disease has emerged as a leading cause of death in countries with devel-oping economies.

Código de aprobación: PP-CVP-GLB-0298

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Primary Aldosteronism: More Common Than Previously Reported 

Guideline-recommended screening for primary aldosteronism in patients with resistant hypertension usually is accomplished by measuring serum aldosterone-renin ratio (ARR); however, screening rates are very low, and ARR might have low sensitivity for disease detection (J Clin Endocrinol Metab 2016; 101:1889). Using a cross-sectional study design, investigators evaluated more than 1000 patients from four geographically diverse U.S. sites.

Código de aprobación: PP-IMU-GLB-0012

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Remote Telehealth Is Noninferior to In-Person Home-Based Delivery of Dementia Care 

Remote sessions might become a convenient alternative to traveling for face-to-face care.

Telehealth programs are both cost-effective and more convenient alternatives to in-person interventions in people with dementia, especially as the dementia progresses. In a noninferiority, randomized, controlled trial, researchers examined two methods of delivering the Care of Persons with Dementia in their Environments (COPE) program — telehealth or face-to-face, home-based sessions.

Código de aprobación: PP-CNS-GLB-1400


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Listeriosis and other Food-borne infectious diseases

Código de aprobación: PP-INT-GLB-0043

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Cardiac Reserve Predicts Hepatorenal Syndrome in Patients with Cirrhosis

TOBI Podhaler: Indicazioni terapeutiche

Hepatorenal syndrome (HRS) is a serious complication of cirrhosis associated with high morbidity and mortality. Recent studies suggest that cardiac dysfunction may play a role in the pathogenesis of HRS.

Código de aprobación: PP-INT-GLB-0030

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Pulmonary Rehabilitation After Hospitalization for COPD Exacerbations

Pulmonary Rehabilitation After Hospitalization for COPD Exacerbations

Pulmonary rehabilitation was associated with fewer rehospitalizations among patients with chronic obstructive pulmonary disease.

In clinical trials, pulmonary rehabilitation lowers risk for readmission following hospitalization for chronic obstructive pulmonary disease (COPD) exacerbations.

Código de aprobación: NON-2022-0146

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Intravenous Contrast Media in Patients with Kidney Disease

In patients with kidney disease, risks associated with intravenous iodinated contrast media before computed tomography (CT)

Código de aprobación: NON-2022-1032

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Gastric Bypass or Sleeve Gastrectomy: Which Has Better Outcomes?

Benefits of bariatric surgery (e.g., longer life expectancy, diabetes remission) have been well documented (NEJM JW Gen Med Jul 1 2021 and Lancet 2021; 397:1830; NEJM JW Gen Med Mar 15 2021 and Lancet2021; 397:293)

Código de aprobación: NON-2022-3971

Ultrasound vs. Landmark-Guided Technique for Medium-Sized Joint Aspiration

Historically, physicians have used anatomic landmarks to guide arthrocentesis. However, we now rec-ognize that the physical exam has limited diagnostic accuracy for detecting joint effusions.

Código de aprobación: NON-2022-7207

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Discovery of a Highly Virulent HIV Variant

This variant has been circulating in the Netherlands since the 1990s, but only now has been recognized.

The virulence of different HIV variants is ref lected by HIV RNA levels in the setpoint window (within 6–24 months of a positive test obtained early after infection) and rate of CD4 cell decline.

Código de aprobación: NON-2022-7132

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Quantifying the Global Impact of Antimicrobial Resistance

Systematic analysis estimates millions of deaths per year are associated with bacterial antimicrobial resistance.

While COVID-19 dominates the world’s attention, bacterial antimicrobial resistance (AMR) is a growing cause of morbidity and mortality.

Código de aprobación: NON-2022-7121

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Many Patients with Alcohol Withdrawal in Intensive Care Don’t Receive Thiamine

The practice is even less common in patients with alcohol use disorder admitted to ICUs for other critical illnesses. Guidelines recommend routine administration of thiamine in patients admitted to intensive care units (ICUs) with alcohol withdrawal because of concerns for nutritional depletion and risk for Wernicke- Korsakoff syndrome.

Código de aprobación: NON-2022-1031

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Poor Sleep and Metabolic Risk

In adults, alcohol intoxication is associated with prolongation of the QT interval corrected for heart rate (QTc). The QTc is influenced by age and sex. Although alcohol intoxication is increasingly common in adolescents, there are no data on the prevalence of QTc prolongation in adolescents with alcohol intoxication.

Código de aprobación: NON-2022-8879

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Noninvasive Algorithm Facilitates Evaluation of MDS for Patients with Unexplained Anemia

A model using 10 clinically accessible variables could exclude or diagnose myelodysplastic syndrome in 86% of tested individuals.

PP-IMU-GLB-0215

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Subclinical Thyroid Dysfunction and Cognitive Function

In a meta-analysis, thyroid dysfunction was not associated with cognitive decline or dementia.

PP-IMU-GLB-0226

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Early Feeding Shortens Hospital Stay in Patients with Mild or Moderate Pancreatitis

Patients started on a low-fat diet on admission were discharged about 5 days earlier than patients in whom feeding was delayed.

PP-IMU-GLB-0216

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Predicting non-alcoholic fatty liver disease

Researchers have developed a risk score based on six clinical variables and two lab tests. Formal diagnosis of nonalcoholic fatty liver disease (NAFLD) requires imaging or biopsy.

Código de aprobación: PP-IMU-GLB-0225

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Hematologic Manifestations of the Newly Defined VEXAS Syndrome

A study of 16 patients provides a greater understanding of this new syndrome. VEXAS (vacuoles, E1 enzyme, Xlinked, autoinflammatory, somatic) syndrome is a newly recognized disease characterized by severe autoinflammatory symptoms, thrombosis, and progressive cytopenias.

Código de aprobación: NON-2021-6160

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Adding Dietary Calcium and Protein Might Prevent Falls and Fractures in Older Adults

Fewer falls and fractures occurred in assisted-living facilities that included extra dairy products in their daily menus.

Código de aprobación: NON-2022-0144

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Gestational Diabetes, Pregnancy Complications, and Long-Term Health Risks

The Centers for Disease Control and Prevention reported that in 2016 the national prevalence of gestational diabetes mellitus (GDM) was 6% among women with live births. Based on this estimate, among the 3.75 million births in the United States in 2019, there were approximately 225,000 preg- nancies complicated by GDM.

Código de aprobación: PP-IMU-GLB-0120

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Mutational Profiling and Cancer-Associated Thrombosis

Six mutations are associated with an increased risk for cancer-associated thrombosis, independent of cancer type. The etiology of cancer-associated thrombosis (CAT) is multifactorial, with influence from cancer stage, chemotherapy, postoperative state/immobility, prior thrombosis history, and presence of vascular access.

Código de aprobación: PP-IMU-GLB-0148

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Physical Activity and Kidney Function in Sedentary Older Adults

About 2.5 hours of activity weekly was associated with significantly slower kidney function decline.Evidence suggest that higher levels of physical activity are associated with slower decline in kidney function.

NON-2022-9879

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Acute Diverticulitis: Two New Guidelines

The American College of Physicians weighs in on diagnosis, treatment, and postepisode management.

NON-2022-3974

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Newly Secreted Antibodies and Risk for Clostridioides difficile Recurrence

Lack of detectable serum antibodies or cells making antibodies against three C. difficile toxins identified patients at risk for CD recurrence.

NON-2022-7205

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Risk factors for local recurrence of large gastrointestinal lesions after endoscopic mucosal resection

Recent advances in endoscopy have increased the frequency of endoscopic lesion detection and have led to significant changes in the treatment of these lesions. Today, therapeutic modalities are being augmented by relatively less invasive endoscopic resections, especially for early-stage cancers and precancerous lesions. The key advantages of endoscopic resections are their minimal invasiveness, short recovery period, protection of gastrointestinal tract integrity and function.

NON-2022-10948

Glycemic Targets for Older Adults with Type 2 Diabetes

 

Apparently, clinicians have not adjusted their practices to accommodate relaxed glycosylated hemoglobin targets.

Código de aprobación: NON-2022-10961

Evaluation and Treatment of Patients with Pancreatic Necrosis

"Patients who develop pancreatic necrosis — especially infected pancreatic necrosis — are at high risk for morbidity and mortality. Accordingly, recent research has focused on preventing pancreatic necrosis and identifying the best treatment strategies for those who develop the condition."

NON-2021-6290

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Adverse Pregnancy Outcomes Are Associated with Future Cardiovascular Risk

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Adverse Pregnancy Outcomes Are Associated with Future Cardiovascular Risk

Preventing serious fall injuries

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Preventing serious fall injuries